On the banks of the Mississippi River in present-day Louisiana, Spanish conquistador Hernando de Soto dies, ending a three-year journey for gold that took him halfway across what is now the United States. In order that Indians would not learn of his death, and thus disprove de Soto's claims of divinity, his men buried his body in the Mississippi River.
In late May 1539, de Soto landed on the west coast of Florida with 600 troops, servants, and staff, 200 horses, and a pack of bloodhounds. From there, the army set about subduing the natives, seizing any valuables they stumbled upon, and preparing the region for eventual Spanish colonization. Traveling through Florida, Georgia, South Carolina, across the Appalachians, and back to Alabama, de Soto failed to find the gold and silver he desired, but he did seize a valuable collection of pearls at Cofitachequi, in present-day Georgia. Decisive conquest also eluded the Spaniards, as what would become the United States lacked the large, centralized civilizations of Mexico and Peru.
As was the method of Spanish conquest elsewhere in the Americas, de Soto ill-treated and enslaved the natives he encountered. For the most part, the Indian warriors they encountered were intimidated by the Spanish horsemen and kept their distance. In October 1540, however, the tables were turned when a confederation of Indians attacked the Spaniards at the fortified Indian town of Mabila, near present-day Mobile, Alabama. All the Indians were killed, along with 20 of de Soto's men. Several hundred Spaniards were wounded. In addition, the Indian conscripts they had come to depend on to bear their supplies had all fled with baggage.
De Soto could have marched south to reconvene with his ships along the Gulf Coast, but instead he ordered his expedition north-westward in search of America's elusive riches. In May 1541, the army reached and crossed the Mississippi River, probably the first Europeans ever to do so. From there, they traveled through Arkansas and Louisiana, still with few material gains to show for their efforts. Turning back to the Mississippi, de Soto died of a fever on its banks on May 21, 1542.
The Spaniards, now under the command of Luis de Moscoso, traveled west again, crossing into north Texas before returning to the Mississippi. With nearly half of the original expedition dead, the Spaniards built rafts and traveled down the river to the sea, and then made their way down the Texas coast to New Spain, finally reaching Veracruz, Mexico, in late 1543.