Franklin James, the lesser-known older brother of Jesse, is born in Clay County, Missouri.

On January 29, 1843, William McKinley, who will become the 25th American president and the first to ride in an automobile, is born in Niles, Ohio. McKinley served in the White House from 1897 to 1901, a time when the American automotive industry was in its infancy. During his presidency, McKinley (who died from an assassin’s bullet in September 1901) took a drive in a Stanley Steamer, a steam-engine-powered auto built in the late 1890s by brothers Francis and Freelan Stanley. The Stanley Motor Carriage Company produced a number of steam-powered vehicles before going out of business in the early 1920s, after being unable to compete with the rise of less expensive gas-powered cars.

Called the U.S.'s first ambassador to Japan, a 14-year-old fisherman by the name of Manjiro is considered America's first Japanese immigrant, arriving in the country on May 7, 1843, by way of a whaling ship.

The first major wagon train to the northwest departs from Elm Grove, Missouri, on the Oregon Trail.

On December 19, 1843, Charles Dickens’ classic story “A Christmas Carol” is published.