In the early hours of January 8, 2016, Mexican authorities apprehend the drug lord Joaquín “El Chapo” Guzmán. It was the third time that the law caught up to El Chapo, a figure whose crimes, influence and mystique rival those of Pablo Escobar.

On the morning of April 21, 2016, Prince, the virtuosic musician who created more than 30 albums and won seven Grammy Awards over a 40-year career, is found dead in Paisley Park, his Minnesota home and recording studio. The cause of death was an accidental overdose of the opioid fentanyl. He was 57 years old.

On May 19, 2016, 66 passengers and crew flying from Cairo to Paris on EgyptAir flight 804 disappeared over the Mediterranean Sea.

As Latin music blared inside Pulse, one of Orlando’s biggest nightclubs on June 12, 2016, a gunman forced his way inside and opened fire on the predominantly gay crowd. In the end, 49 people were dead and dozens more injured, in what was, at the time, the deadliest mass shooting in modern U.S. history.

On July 14, 2016, thousands gathered along the seafront of Nice, France to celebrate Bastille Day—the country's independence holiday. The mood turned from joy to horror, when a white truck barreled through a pedestrian-filled closed street. In the end, 86 were dead, including 10 children, and over 400 spectators were left injured.

Ninety-five years after women were first granted the right to vote, on July 28, 2016, former Secretary of State, Senator and First Lady Hillary Rodham Clinton makes history by accepting the Democratic Party's nomination for president, becoming the first woman to lead a major U.S. political party.

At an NFL preseason game on August 26, 2016, San Francisco 49ers quarterback Colin Kaepernick remains seated as other players stand to observe the national anthem. This simple action, which Kaepernick makes no attempt to broadcast to the public, gives rise to a controversy that will bring to light the racial tensions within American sports, determine the fate of Kaepernick’s football career and reverberate across the sporting world for years to come.

On September 4, 2016, Mother Teresa, a Roman Catholic nun who dedicated her life to caring for the destitute in India, officially becomes Saint Teresa of Calcutta, almost two decades after her death on September 5, 1997.

More than 15 years after it was first established, the National Museum of African American History and Culture opens on the National Mall on September 24, 2016. Barack Obama, the nation’s first African American president, leads the ceremony and officially opens the museum by ringing the Freedom Bell, a bell from an African American Baptist church founded in 1776.

In the early hours of November 3, 2016, the Chicago Cubs win their first World Series championship since 1908, beating the Cleveland Indians, 8-7, in a thrilling Game 7 delayed by rain. "Let It Reign," reads the headline in the next day's Chicago Tribune sports section. The win snaps the “Billy Goat Curse,” one of the more infamous sports curses, and baseball's longest World Series title drought.

On November 4, 2016, the Paris Agreement comes into effect. A sweeping international pledge to dramatically reduce carbon emissions, the agreement remains a potential turning point in the history of human relations with the Earth’s climate.

On December 9, 2016, the World Anti-Doping Agency details a vast "institutional conspiracy" involving Russian officials and more than 1,000 athletes in systematic doping at major athletic competitions, including the Olympics. A second WADA report says the conspiracy involves the Russian Sports Ministry, national anti-doping agency and the FSB intelligence service and that the cheating and cover-ups were on an "unprecedented scale" from 2011-15.