C. 1350-1600: The Iroquois Confederacy, also called Haudenosaunee, is formed as an alliance between five nations—Cayuga, Mohawk, Oneida, Onondaga and Seneca—hoping to end constant warring. The Tuscarora tribe joined in 1722. The alliance had its own constitution called "The Great Law of Peace."
1492: Christopher Columbus lands on a Caribbean Island after three months of traveling. Believing at first that he had reached the East Indies, he describes the natives he meets as “Indians.” On his first day, he orders six natives to be seized as servants.
April 1513: Spanish explorer Juan Ponce de Leon lands on continental North America in Florida and makes contact with Native Americans.
February 1521: Ponce de Leon departs on another voyage to Florida from San Juan to start a colony. Months after landing, Ponce de Leon is attacked by local Native Americans and fatally wounded.
May 1539: Spanish explorer and conquistador Hernando de Soto lands in Florida to conquer the region. He explores the South under the guidance of Native Americans who had been captured along the way.
October 1540: De Soto and the Spaniards plan to rendezvous with ships in Alabama when they’re attacked by Native Americans. Hundreds of Native Americans are killed in the ensuing battle.
C. 1595: Pocahontas is born, daughter of Chief Powhatan.
1607: Pocahontas’ brother kidnaps Captain John Smith from the Jamestown colony. Smith later writes that after being threatened by Chief Powhatan, he was saved by Pocahontas. This scenario is debated by historians.
C. 1613: First Covenant Chain formed between the Iroquoois Confederacy and Dutch settlers. Codified in a famed two-row wampum belt, the agreement promised harmonious mutual coexistence at a time when European settlers and traders were beginning to encroach on Iroquois territory.
1613: Pocahontas is captured by Captain Samuel Argall in the first Anglo-Powhatan War. While captive, she learns to speak English, converts to Christianity and is given the name “Rebecca.”
1622: The Powhatan Confederacy nearly wipes out Jamestown colony.
1680: A revolt of Pueblo Native Americans in New Mexico threatens Spanish rule over New Mexico.
1754: The French and Indian War begins, pitting the two groups against English settlements in the North.